Maulidan Firdaus, Muhammad Iqbal Daniswara,
Khoirul Jamaluddin, Novi Andriani
Sebelas Maret University – Surakarta (Indonesia)
Abstract. Methicillin-resistant Staphylococcus aureus (MRSA) bacteria that colonize diabetic foot ulcers can cause dangerous infections and even amputations. To improve the healing process, hydrogel wound dressing loaded with antibacterial agents can be selected as viable alternatives to reduce MRSA colonization and infection. This review highlights the potential use of water hyacinth cellulose (Eichornia crassipes) as a base for hydrogel plaster and red ginger rhizome (Zingiber officinale var. Rubrum) as an antibacterial agent. Comprehensive studies show that water hyacinth weed that contains high cellulose has the potency to be converted into hydrogels. In addition, further studies show that the active compounds of red ginger rhizome extract such as 6-gingerol, gingerenone-A, and 6-shogaol are proven to inhibit MRSA which could be incorporated into hydrogels. These findings prove that the hydrogel derived from water hyacinth cellulose and the active compounds of red ginger extract is very promising for the future as a new alternative to diabetic wound dressing.
Keywords: diabetic wound; hydrogel plaster; MRSA; red ginger; water hyacinth